反応 #742249

反応方程式

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

反応条件

後処理

1. 1
   温度Then the reaction mixture was heated to reflux
2. 2
   温度After refluxing for 31 hours the mixture
3. 3
   温度was cooled down
4. 4
   その他evaporated to dryness
5. 5
   その他The resulting dark oil was purified by chromatography
6. 6
   その他to yield a colourless oil

実験手順

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

出典