反応 #74223

反応方程式

benzimidazol-5-amine

4-bromobenzylbromide

K2CO3

→

N,N-Bis(4-bromobenzyl)-1H-benzo[d]imidazol-5-amine

反応条件

後処理

1. 1
   その他The compound was synthesized
2. 2
   その他rt 18.49 min (98.4%)

実験手順

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 4-bromobenzylbromide (550 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.153 g (32.5%); MS m/z: 472.3 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 4.63 (s, 4H); 6.66-6.67 (m, 1H); 6.71 (dd, 1H, 4J=2.4 Hz, 3J=8.9 Hz); 7.22-7.24 (m, 4H); 7.34 (d, 1H, 3J=8.9 Hz); 7.48-7.50 (m, 4H); 7.93 (s, 1H); 11.99 (br s, 1H; HPLC (METHOD [A]): rt 18.49 min (98.4%)

出典