反応 #74204

反応方程式

NaOH

benzimidazol-5-amine

4-methoxybenzaldehyde

NaBH4

→

N-(4-Methoxybenzyl)-3H-benzo[d]imidazol-5-amine

反応条件

後処理

1. 1
   その他Alternatively the compound was synthesized

実験手順

Alternatively the compound was synthesized starting from benzimidazol-5-amine (2.66 g; 20 mmol; 1 eq.), 4-methoxybenzaldehyde (3.26 g; 2.9 ml; 24 mmol; 1.2 eq.), NaBH4 (1.14 g; 30 mmol; 1.5 eq.) and 5 N NaOH (20 ml; 100 mmol; 5 eq.) according to method 2; Yield: 4.53 g (89.5%); MS m/z: 254.3 [M+H]+

出典