反応 #74132

反応方程式

Water

cesium carbonate

p-methoxybenzyl chloride

4-iodo-3-(3-nitrophenyl)-1H-pyrazole

→

4-iodo-1-(4-methoxybenzyl)-3-(3-nitrophenyl)-1H-pyrazole

溶媒

dimethylformamide

反応条件

後処理

1. 1
   抽出the product extracted with dichloromethane
2. 2
   乾燥The organic phase was dried over sodium sulphate
3. 3
   その他the solvent evaporated under reduced pressure
4. 4
   その他2.4 g (86%) of the title compound crystallized from a mixture diethylether-diisopropylether

実験手順

2 g (6.3 mmol) of 4-iodo-3-(3-nitrophenyl)-1H-pyrazole were dissolved in 20 ml of dry dimethylformamide and 2.46 g (7.5 mmol) of cesium carbonate and 0.85 ml (6.3 mmol) of p-methoxybenzyl chloride were added successively. The reaction mixture was heated at 70° C. under stirring for 5 hours. Water was then added and the product extracted with dichloromethane. The organic phase was dried over sodium sulphate and the solvent evaporated under reduced pressure. 2.4 g (86%) of the title compound crystallized from a mixture diethylether-diisopropylether.

出典