反応 #73934

反応方程式

2-bromo-1-phenylethanone

(2,4-dichlorophenyl)-N-methylmethanamine

Triethylamine

→

title compound

収率 90.0%

2-((2,4-dichlorobenzyl)(methyl)amino)-1-phenylethanone

収率 90.0%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他Into a 50-mL 3-necked round-bottom flask purged
2. 2
   温度maintained with an inert atmosphere of nitrogen
3. 3
   workup.STIRRINGThe resulting solution was stirred for 1 h at 20° C. in an oil bath
4. 4
   ろ過The solids were filtered out
5. 5
   濃縮The resulting mixture was concentrated under vacuum

実験手順

Into a 50-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-bromo-1-phenylethanone (1 g, 5.05 mmol, 1.00 equiv) in 1,4-dioxane (20 mL) and (2,4-dichlorophenyl)-N-methylmethanamine (1.1 g, 5.82 mmol, 1.15 equiv). Triethylamine (2 g, 19.80 mmol, 3.92 equiv) was added dropwise with stirring at 20° C. The resulting solution was stirred for 1 h at 20° C. in an oil bath. The solids were filtered out. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:50). This resulted in 1.4 g (90%) of the title compound as a yellow oil.

出典