反応 #73926

反応方程式

ethyl 2-(benzyl((diethoxyphosphoryl)methyl)amino)acetate

→

ethyl 2-((diethoxyphosphoryl)methylamino)acetate

溶媒

ethanol

acetic acid

反応条件

後処理

1. 1
   その他A 250-mL pressure tank reactor was purged
2. 2
   その他flushed
3. 3
   温度maintained with a hydrogen atmosphere
4. 4
   ろ過The solids were filtered out
5. 5
   濃縮the resulting mixture was concentrated under vacuum

実験手順

A 250-mL pressure tank reactor was purged, flushed and maintained with a hydrogen atmosphere, then, was added a solution of ethyl 2-(benzyl((diethoxyphosphoryl)methyl)amino)acetate (8.0 g, 23.32 mmol, 1.00 equiv) in ethanol (180 mL), acetic acid (10 mL), Pd/C (0.9 g). The resulting solution was stirred at 20 atm for 32 h at 50° C. The solids were filtered out, and the resulting mixture was concentrated under vacuum. This resulted in 6.0 g (82%) of the acetic acid salt of ethyl 2-((diethoxyphosphoryl)methylamino)acetate as a brown oil.

出典