反応 #7389

反応方程式

5-chloro-1-benzofuran-2-carboxylic acid

→

title compound

5-Chloro-1-benzofuran

溶媒

1-methyl-2-pyrrolidinone

反応条件

後処理

1. 1
   温度The reaction vessel was cooled to room temperature
2. 2
   その他the combined mixtures partitioned between water and diethyl ether
3. 3
   洗浄The organic layer was washed with water and brine
4. 4
   乾燥dried (over magnesium sulphate)
5. 5
   濃縮concentrated under reduced pressure

実験手順

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

出典