反応 #73881

反応方程式

1-(4′-{3-Methyl-4-[6-bromo-pyridin-2-ylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester

sodium bicarbonate

DME

o-tolylboronic acid

→

title compound

1-(4′-{3-Methyl-4-[6-(2-methyl-phenyl)-pyridin-2-ylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester

溶媒

EtOAc

H2O

反応条件

後処理

1. 1
   温度the mixture was cooled to room temperature
2. 2
   抽出extracted with H2O (2×10 mL)
3. 3
   乾燥The organic layer was dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated
6. 6
   その他the crude residue was purified on reverse-phase preparative HPLC

実験手順

1-(4′-{3-Methyl-4-[6-bromo-pyridin-2-ylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester (0.050 g, 0.09 mmol), o-tolylboronic acid (0.016 g, 0.12 mmol), sodium bicarbonate (0.040 g, 0.48 mmol), and bis(diphenylphosphino)ferrocene)-dichloropalladium(II) (0.007 g, 0.009 mmol) were combined in 3:1 DME:H2O (2 mL) and warmed with stirring to 70° C. After 3 hrs, the mixture was cooled to room temperature diluted with EtOAc (30 mL) and extracted with H2O (2×10 mL). The organic layer was dried over MgSO4, filtered and concentrated, and the crude residue was purified on reverse-phase preparative HPLC to afford the title compound.

出典