反応 #736396

反応方程式

4-chloro-3-methoxy-2-methyl-pyridine

2,2,3,3,3-pentafluoropropanol

potassium tert-butoxide

→

3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度After being refluxed for 40 hours
2. 2
   workup.ADDITIONwas added
3. 3
   ろ過the insoluble substance was filtered off
4. 4
   濃縮The filtrate was concentrated
5. 5
   その他purified by column chromatography

実験手順

To 2,2,3,3,3-pentafluoropropanol (21 ml) were added in small portions, potassium tert-butoxide (23.6 g) and then 4-chloro-3-methoxy-2-methyl-pyridine (7.5 g). After being refluxed for 40 hours, the reaction mixture was cooled, to which ethyl acetate was added and the insoluble substance was filtered off. The filtrate was concentrated and purified by column chromatography, to give 3-methoxy-2-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyridine (1.7 g) as a light yellow oil while 4.1 g of the starting material was recovered at the same time.

出典