反応 #736393

反応方程式

4-Chloro-3-methoxy-2-methylpyridine

sodium

ethanol

→

4-ethoxy-3-methoxy-2-methyl-pyridine

反応条件

後処理

1. 1
   温度the solution was refluxed
2. 2
   温度by heating for 10 hours
3. 3
   その他The solvent was evaporated
4. 4
   workup.ADDITIONthe residue was added to ice water, which
5. 5
   抽出was extracted with chloroform
6. 6
   洗浄washed with water
7. 7
   その他dried
8. 8
   その他evaporated
9. 9
   その他The residue was purified by column chromatography on silica gel

実験手順

4-Chloro-3-methoxy-2-methylpyridine (3.14 g) was added to a solution of sodium (2.0 g) in ethanol (30 ml), and the solution was refluxed by heating for 10 hours. The solvent was evaporated and the residue was added to ice water, which was extracted with chloroform, washed with water, dried and evaporated. The residue was purified by column chromatography on silica gel, to give 4-ethoxy-3-methoxy-2-methyl-pyridine (2.6 g) as a light brown oil.

出典