反応 #735968

反応方程式

monobutyl phosphate

sodium hydroxide

glycidol

oxirane

→

sodium butylglyceryl phosphate

収率 81.5%

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他at 70° C.
3. 3
   その他The reaction product was isolated from the reaction solution by HPLC
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

20 g (0.13 moles) of monobutyl phosphate having a purity of 99% (AV1=360.6, AV2=721.3) was charged into a reactor, to which 129 ml of 1N sodium hydroxide aqueous solution was added and agitated, followed by heating to 70° C. to make a uniform system. At this moment, the acid value of the reaction system was 46.7. While keeping the reaction system at 70° C., 42.7 g of glycidol (the oxirane value=683.7) was gradually dropped, followed by agitation at the temperature for 6 hours, at which the acid value of the reaction system was approximately zero, revealing that the conversion of phosphoric monoester was almost 100%. The reaction product was isolated from the reaction solution by HPLC and the solvent was distilled off under reduced pressure, thereby obtaining 26.5 g of sodium butylglyceryl phosphate (yield: 81.5%).

出典