反応 #73584

反応方程式

metformin

hydrochloric acid

→

metformin hydrochloride

収率 76.4%

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The resulting crystal was filtered
2. 2
   洗浄washed with acetone
3. 3
   その他dried
4. 4
   温度with heated air at 70° C.

実験手順

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

出典