反応 #73579

反応方程式

water

sodium hydroxide

metformin hydrochloride

acetone

→

metformin acetate

収率 92.4%

反応条件

後処理

1. 1
   ろ過The resulting crystal was filtered
2. 2
   洗浄washed with acetone
3. 3
   workup.ADDITION0.2 L of water and 1 L of acetic acid were added
4. 4
   workup.STIRRINGstirred
5. 5
   ろ過The resulting crystal was filtered
6. 6
   洗浄washed with acetone
7. 7
   その他dried at 60° C.

実験手順

0.4 L of water, 241.50 g of sodium hydroxide, 9 L of acetone and 1 Kg of metformin hydrochloride were added to a 20 L reactor, and stirred for 2 hours and 40 minutes at room temperature. The resulting crystal was filtered and washed with acetone. 0.2 L of water and 1 L of acetic acid were added and stirred. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 1,056 g of metformin acetate (yield: 92.4%).

出典