反応 #73578

反応方程式

metformin hydrochloride

sodium acetate trihydrate

→

metformin acetate

収率 51.6%

溶媒

water

反応条件

後処理

1. 1
   ろ過Then the resulting crystal was filtered
2. 2
   洗浄washed with acetone
3. 3
   その他dried at 60° C.

実験手順

20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).

出典