反応 #73577

反応方程式

sodium hydroxide

metformin hydrochloride

acetic acid

→

metformin acetate

収率 73.0%

溶媒

water

反応条件

後処理

1. 1
   workup.DISSOLUTIONto dissolve thoroughly
2. 2
   ろ過The resulting crystal was filtered
3. 3
   洗浄washed with acetone
4. 4
   その他dried at 60° C.

実験手順

20.0 g (1 equivalent) of metformin hydrochloride and 30 Ml of water, and then 10 Ml (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 1.23 g (1.5 equivalents) of aqueous solution of sodium hydroxide was added to the reaction solution. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 16.7 g of metformin acetate (yield: 73.0%).

出典