反応 #73576

反応方程式

sodium hydroxide

metformin hydrochloride

acetic acid

→

metformin acetate

収率 52.7%

溶媒

water

反応条件

後処理

1. 1
   workup.DISSOLUTIONto dissolve thoroughly
2. 2
   ろ過The resulting crystal was filtered
3. 3
   洗浄washed with acetone
4. 4
   その他dried at 60° C.

実験手順

1 Kg (1 equivalent) of metformin hydrochloride and 2 L of water, and then 0.5 L (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 289.8 g (1.2 equivalents) of aqueous solution of sodium hydroxide were added to the reaction solution for 1 hour. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 601 g of metformin acetate (yield: 52.7%).

出典