反応 #73509

反応方程式

tert-butylamine

6-chloropyridine-3-sulfonyl chloride

→

N-tertbutyl-6-chloropyridine-3-sulfonamide

収率 79.0%

溶媒

DCM

DCM

反応条件

後処理

1. 1
   workup.ADDITIONare added portionwise, at 0° C.
2. 2
   洗浄washed with water (1 L), saturated NaHCO3 solution (1 L) and brine (1 L)
3. 3
   乾燥dried over Na2SO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under reduced pressure

実験手順

To a mixture of 17.3 mL (165 mmol) of tert-butylamine and 69 mL (495 mmol) of TEA in 330 mL of DCM are added portionwise, at 0° C., 35 g (165 mmol) of 6-chloropyridine-3-sulfonyl chloride. After stirring for 2 hours at 0° C., the reaction medium is taken up in 600 mL of DCM, washed with water (1 L), saturated NaHCO3 solution (1 L) and brine (1 L), dried over Na2SO4, filtered and concentrated under reduced pressure. 32.4 g of N-tertbutyl-6-chloropyridine-3-sulfonamide are obtained in the form of a white solid.

出典