反応 #73476

反応方程式

{1-[4-(Isoquinolin-6-ylamino)-1-(4-methoxy-phenyl)-cyclohexyl]-propyl}-carbamic acid benzyl ester

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title compound

[4-(1-Amino-propyl)-4-(4-methoxy-phenyl)-cyclohexyl]-isoquinolin-6-yl-amine

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   その他the reaction mixture was evaporated to dryness

実験手順

48 mg (91.7 μmol) of {1-[4-(Isoquinolin-6-ylamino)-1-(4-methoxy-phenyl)-cyclohexyl]-propyl}-carbamic acid benzyl ester (99) were dissolved in 300 μL of dry methanol and 9.7 μg of palladium on activated charcoal (10%) were added. The mixture was stirred under a hydrogen atmosphere until conversion was complete. The catalyst was filtered off and the reaction mixture was evaporated to dryness to give the title compound. Rt=0.89 min (Method 19). Detected mass: 390.3 (M+H+).

出典