反応 #73444

反応方程式

4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Dess-Martin periodinane

→

4-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

溶媒

DCM

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   その他is quenched with sat NaHCO3
3. 3
   洗浄washed
4. 4
   抽出extracted with DCM
5. 5
   その他The organics are dried
6. 6
   その他evaporated

実験手順

To a solution of 4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (5 g, 20.4 mmol) in DCM (100 mL), Dess-Martin periodinane (12.97 g, 30.6 mmol) is added. After completion of the reaction as judged by TLC the reaction is quenched with sat NaHCO3, washed with sat sodium thiosulfate and extracted with DCM. The organics are dried and evaporated and used crude in the next step.

出典