反応 #73435

反応方程式

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

NCS

→

title compound

(4-Chloro-5-cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

溶媒

AcOH

water

ethyl acetate

反応条件

後処理

1. 1
   温度The reaction is cooled to room temperature
2. 2
   洗浄The organic layer is washed with 500 mL of water
3. 3
   その他to remove the acid
4. 4
   乾燥The organic layer is dried (sodium sulfate)
5. 5
   濃縮concentrated to an oil (352 mg)

実験手順

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester (0.25 g, 1.024 mmol) is dissolved in AcOH (7.31 mL) and NCS (0.205 g, 1.53 mmol) is added and the reaction is heated to 79° C. for 2 hours. The reaction is cooled to room temperature and diluted with water and ethyl acetate. The organic layer is washed with 500 mL of water to remove the acid. The organic layer is dried (sodium sulfate) and concentrated to an oil (352 mg) to obtain the title compound that is used without further purification. MS (ESI) m/z 279.00 (M+1).

出典