反応 #73359

反応方程式

1-benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

formamidine hydrochloride

NaOEt

→

title compound

(±)-7-Benzyl-8-methyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

溶媒

EtOH

反応条件

後処理

1. 1
   その他Reaction
2. 2
   濃縮is concentrated in vacuo

実験手順

A mixture of 1-benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester (1.0 g, 3.9 mmol), formamidine hydrochloride (930 mg, 11.6 mmol), and EtOH (6 mL) is treated with NaOEt solution (5.5 mL, 13.57 mmol, 21% w/w in EtOH) and the reaction is stirred at 90° C. for 2 h. Reaction is concentrated in vacuo after adjusting to pH 6. Residue is via semi-prep HPLC (C18; 10-100% I/H2O with 0.1% NH4OH) to give the title compound. MS (ESI) m/z 256.0 (M+1).

出典