反応 #73358

反応方程式

4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester

potassium tert-butoxide

→

(±)-1-Benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

溶媒

toluene

反応条件

後処理

1. 1
   その他The mixture is then partitioned between DCM and saturated aqueous NH4Cl
2. 2
   その他The organic layer is removed
3. 3
   乾燥dried over anhydrous Na2SO4
4. 4
   濃縮concentrated
5. 5
   その他The crude residue is used without further purification

実験手順

A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.

出典