反応 #73290

反応方程式

NaHCO3

THF

HCl

2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol

→

4-(2-Hydroxyethyl)cyclohexanone

溶媒

acetone

反応条件

後処理

1. 1
   抽出was then extracted with ethyl acetate
2. 2
   洗浄The organic extracts were washed with water
3. 3
   乾燥with saturated NaCl, then dried (MgSO4)
4. 4
   濃縮concentrated in vacuo
5. 5
   その他The crude product was used in the next reaction without further purification

実験手順

2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification. 1H NMR(CDCl3): 3.75 (m, 2H), 2.36 (m, 4H), 1.20-2.13 (m, 7H).

出典