反応 #73141

反応方程式

(R)-2-(3-(aminomethyl)pyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

methane sulfonylchloride

TFA

→

title compound

(R)—N-((4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)pyridin-3-yl)methyl)methanesulfonamide

反応条件

実験手順

The title compound was prepared similarly to the methods described in Example 114, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 105) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91) and with methane sulfonylchloride instead of chloromethylcarbonate. LCMS (0.05% TFA): 445.2 m/z (M+H)+; 1H-NMR (MeOD, 500 MHz): δ: 8.62 (s, 1H), 8.50 (d, 1H, J=5.0 Hz), 8.05 (s, 1H), 7.82 (d, 1H, J=5.0 Hz), 4.54 (s, 2H), 4.36 (m, 1H), 4.28 (m, 1H), 3.31 (s, 3H), 2.77 (s, 3H), 2.01˜1.58 (m, 10H), 0.78 (t, 3H, J=7.5 Hz).

出典