反応 #7312

反応方程式

5-chlorobenzotriazole

chloroacetone

potassium carbonate

potassium iodide

→

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

1-(6-chlorobenzotriazol-1-yl)-propan-2-one

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The mixture is subsequently filtered
2. 2
   濃縮the filtrate concentrated by evaporation in a vacuum
3. 3
   その他the residue purified by flash chromatography

実験手順

A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.

出典