反応 #73064

反応方程式

7-bromo[1,5]naphthyridin-4-ol

nitric acid

NaOH

→

7-bromo-3-nitro[1,5]naphthyridin-4-ol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度The reaction mixture was cooled to 50° C.
3. 3
   ろ過The resulting precipitate was filtered
4. 4
   洗浄washed with water
5. 5
   その他dried over vacuum for 3 days

実験手順

A mixture of 7-bromo[1,5]naphthyridin-4-ol (33 g, 0.147 mol) and fuming nitric acid (350 mL) was heated at reflux (90° C. internal reaction vessel temperature) for 3 hours. The reaction mixture was cooled to 50° C., poured over 1 L of ice and neutralized to pH 2-3 with a solution of 50% aqueous NaOH. The resulting precipitate was filtered, washed with water, and dried over vacuum for 3 days to yield 25.1 g of 7-bromo-3-nitro[1,5]naphthyridin-4-ol as a yellow crystalline solid.

出典