反応 #73028

反応方程式

Trimethylorthobutyrate

pyridine hydrochloride

4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol

→

4-[(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol

溶媒

toluene

反応条件

後処理

1. 1
   温度The reaction mixture was heated
2. 2
   温度at reflux for 4 hours
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他The residue was triturated with acetonitrile
5. 5
   ろ過the filtered

実験手順

Trimethylorthobutyrate (1.9 mL, 12.0 mmol) and pyridine hydrochloride (58 mg, 0.5 mmol) were added to a suspension of 4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol (10.0 mmol) in toluene (50 mL). The reaction mixture was heated at reflux for 4 hours and then concentrated under reduced pressure. The residue was triturated with acetonitrile and the filtered to provide 4-[(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol as a tan solid.

出典