反応 #73019

反応方程式

1-{[(3-nitro[1,5]naphthyridin-4-yl)amino]methyl}cyclohexanol

→

1-{[(3-amino[1,5]naphthyridin-4-yl)amino]methyl}cyclohexanol

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他was hydrogenated at 50 psi (3.5×105 Pa) overnight on a Parr apparatus
2. 2
   ろ過The reaction mixture was filtered through CELITE
3. 3
   ろ過filter agent, which
4. 4
   洗浄was rinsed with methanol afterwards
5. 5
   濃縮The filtrate was concentrated

実験手順

A mixture of 1-{[(3-nitro[1,5]naphthyridin-4-yl)amino]methyl}cyclohexanol (4.55 g, 15.1 mmol) and 5% platinum on carbon (0.50 g) in acetonitrile (100 mL) was hydrogenated at 50 psi (3.5×105 Pa) overnight on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent, which was rinsed with methanol afterwards. The filtrate was concentrated to give 1-{[(3-amino[1,5]naphthyridin-4-yl)amino]methyl}cyclohexanol. The 1-{[(3-amino[1,5]naphthyridin-4-yl)amino]methyl}cyclohexanol was concentrated from chloroform several times to remove residual methanol and was used directly onto the next step.

出典