反応 #72925

反応方程式

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

収率 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

収率 92.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   ろ過The catalyst was then filtered on celite
2. 2
   その他the filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   洗浄washed with aqueous NaHCO3
5. 5
   乾燥The solvent was dried over sodium sulfate
6. 6
   その他removed under reduced pressure
7. 7
   その他to give

実験手順

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

出典