反応 #72924

反応方程式

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

収率 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

収率 83.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The resulting solution was refluxed for 6 hours
2. 2
   その他The solvent was then removed in vacuo
3. 3
   その他the residue partitioned between dichloromethane and water
4. 4
   乾燥The organic layer was dried over sodium sulfate
5. 5
   その他evaporated to dryness

実験手順

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

出典