反応 #72918

反応方程式

1-tert-butyl-4-(4-nitrophenyl)piperazine

ammonium chloride

→

amine

収率 89.6%

4-(4-tert-butylpiperazin-1-yl)phenylamine

収率 89.6%

溶媒

methanol

water

反応条件

後処理

1. 1
   温度the suspension was cooled
2. 2
   ろ過filtered
3. 3
   workup.ADDITIONpH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase
4. 4
   抽出Extraction with dichloromethane

実験手順

To a solution of 840 mg (3.189 mmol) of 1-tert-butyl-4-(4-nitrophenyl)piperazine in 24 mL of methanol, 904 mg (16.9 mmol) of ammonium chloride dissolved in 6 mL of water and 552 mg (9.886 mmol) of iron were added. After 7 hours, the suspension was cooled and filtered. pH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase. Extraction with dichloromethane yielded 667 mg of the title amine.

出典