反応 #728027

反応方程式

H2SO4

HNO3

(4-Bromo-phenyl)-(4-nitro-phenyl)-methanone

→

(4-Bromo-3-nitro-phenyl)-(-4-nitro-phenyl)-methanone

収率 78.0%

溶媒

dichloroethane

反応条件

後処理

1. 1
   workup.STIRRINGto stir
2. 2
   その他resulting in precipitation of the product
3. 3
   ろ過The product was filtered
4. 4
   その他dried

実験手順

The crude (4-Bromo-phenyl)-(4-nitro-phenyl)-methanone (15 g, 49 mmol) was dissolved in 45 mL of dichloroethane and added dropwise via addition funnel to a mixture of concentrated H2SO4(aq) (21 mL, 392 mmol) and fuming HNO3(aq) (15.7 mL, 392 mmol). The mixture was stirred at 60° C. overnight. Subsequently the mixture was poured over ice water and allowed to stir resulting in precipitation of the product. The product was filtered and dried affording 78% yield of the desired (4-Bromo-3-nitro-phenyl)-(-4-nitro-phenyl)-methanone (13.1 g, 38 mmol).

出典