反応 #727696

反応方程式

sodium hydrogencarbonate

2-(4-[1,3]dioxolan-2-yl-3-fluoro-benzyloxy)-pyridine

tetrahydrofuran

hydrochloric acid

→

title compound

収率 99.3%

2-Fluoro-4-(pyridin-2-yloxymethyl)-benzaldehyde

収率 99.3%

溶媒

methanol

反応条件

後処理

1. 1
   温度This mixture was cooled to 0° C.
2. 2
   抽出after which it was extracted with ethyl acetate
3. 3
   その他The organic layer was separated
4. 4
   洗浄washed with water
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   ろ過filtered
7. 7
   濃縮The filtrate was concentrated under a reduced pressure

実験手順

To a solution of 2-(4-[1,3]dioxolan-2-yl-3-fluoro-benzyloxy)-pyridine (2.17 g, 7.88 mmol) described in Manufacturing Example 204-1-4 in methanol (10 mL) and tetrahydrofuran (10 mL) was added 5 N hydrochloric acid (8.43 mL, 8.43 mmol). This solution was stirred for 15 minutes at room temperature. This mixture was cooled to 0° C. and neutralized with a saturated sodium hydrogencarbonate aqueous solution, after which it was extracted with ethyl acetate. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (1.81 g). The title compound was used in the following reaction without any further purification.

出典