反応 #72760

反応方程式

6-bromo-2-isopropyl-4-nitro-1H-benzo[d]imidazole

1-(bromomethyl)naphthalene

K2CO3

→

crude product

収率 102.6%

6-bromo-2-(1-methylethyl)-1-(1-naphthalenylmethyl)-4-nitro-1H-benzimidazole

収率 102.6%

溶媒

DMF

反応条件

後処理

1. 1
   温度It was cooled to room temperature
2. 2
   ろ過filtered
3. 3
   workup.ADDITIONThe filtrate was then poured into water (1 L)
4. 4
   ろ過It was then filtered
5. 5
   その他to afford a solid
6. 6
   洗浄that was washed with water
7. 7
   その他dried in-vacuo

実験手順

A mixture of 6-bromo-2-isopropyl-4-nitro-1H-benzo[d]imidazole (4.7 g), 1-(bromomethyl)naphthalene (4.01 g) and K2CO3 (4.55 g) in DMF (150 mL) was stirred at 80° C. for 2 h. It was cooled to room temperature and filtered. The filtrate was then poured into water (1 L). It was then filtered to afford a solid that was washed with water and then dried in-vacuo to afford the crude product (7.2 g). LC-MS: m/e=425 [M+1]+

出典