反応 #726680

反応方程式

2-ethyl-1-butanol

triethylenediamine

p-toluenesulfonyl chloride

→

title compound

収率 95.6%

Toluene-4-sulfonic acid 2-ethylbutyl ester

収率 95.6%

溶媒

DCM

DCM

反応条件

後処理

1. 1
   抽出extracted with 1.0N NaOH (2×40 mL)
2. 2
   その他The organic layer was collected
3. 3
   乾燥dried over anhydrous sodium sulfate
4. 4
   ろ過filtered
5. 5
   その他isolated by rotary evaporation

実験手順

To a solution of 2-ethyl-1-butanol (1.00 g, 9.79 mmol), triethylenediamine (1.32 g, 11.7 mmol) in DCM (30 mL, 0.5 mol) cooled to 0° C. was added p-toluenesulfonyl chloride (1.96 g, 10.3 mmol) in DCM (10 mL) The reaction mixture was stirred for 30 min, and extracted with 1.0N NaOH (2×40 mL). The organic layer was collected, dried over anhydrous sodium sulfate, filtered, and isolated by rotary evaporation to give the title compound (2.40 g).

出典