反応 #726616

ord-de5f2605f979439c852160bc03a80a9d

反応方程式

CN([C@H]1CC[C@H](C(=O)O)CC1)S(=O)(=O)C(C)(C)C
Trans-4-(N-methyl-tert-butylsulfonylamino)cyclohexanecarboxylic acid
Nc1ccc(-c2ccccc2)cc1N
4-phenyl-1,2-phenylenediamine
→
CN([C@H]1CC[C@H](c2nc3ccc(-c4ccccc4)cc3[nH]2)CC1)S(=O)(=O)C(C)(C)C
title compound
CN([C@H]1CC[C@H](c2nc3ccc(-c4ccccc4)cc3[nH]2)CC1)S(=O)(=O)C(C)(C)C
2-{trans-4-(N-methyl-tert-butylsulfonylamino)cyclohexyl}-5-phenylbenzimidazole

反応物

CN([C@H]1CC[C@H](C(=O)O)CC1)S(=O)(=O)C(C)(C)C
Trans-4-(N-methyl-tert-butylsulfonylamino)cyclohexanecarboxylic acid
Nc1ccc(-c2ccccc2)cc1N
4-phenyl-1,2-phenylenediamine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他ring closure condensation under the same conditions
  2. 2
    その他followed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=10:1)

実験手順

Trans-4-(N-methyl-tert-butylsulfonylamino)cyclohexanecarboxylic acid and 4-phenyl-1,2-phenylenediamine were allowed to undergo ring closure condensation under the same conditions as described in Example 1-3), followed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=10:1) to give the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07691860B2uspto-grants-2010_04