反応 #725917

反応方程式

2-(4-nitrophenoxy)propionic acid methyl ester

2-(4-Nitro-phenoxy)-propionic acid methyl ester

→

47

収率 85.3%

2-(4-Nitro-phenoxy)-propionic acid

収率 85.3%

溶媒

HCl

反応条件

後処理

1. 1
   温度was refluxed for 8 hours
2. 2
   ろ過Crude 47 was filtered
3. 3
   その他dried
4. 4
   その他recrystallised from a mixture of ethyl acetate:hexane (1:5)

実験手順

A mixture of 2-(4-nitrophenoxy)propionic acid methyl ester 35 (50 g) and concentrated HCl (500 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 47 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 47 (40 g, 85.3%) as a white powder. M.p: 139-141° C.

出典