反応 #7240

反応方程式

2-(hydroxymethyl)-3-methylpyridine

→

3-methylpyridine-2-carboxaldehyde

収率 64.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   ろ過then filtered through celite
2. 2
   濃縮The filtrate was concentrated

実験手順

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

出典