反応 #722507

反応方程式

3-(3-(4-(4-Chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydroindole

3-(3-(4-(4-chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydroindole

potassium carbonate

methyl iodide

→

3-(3-(4-(4-chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methylindole

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 2 hours
3. 3
   その他the solvent was evaporated under reduced pressure
4. 4
   workup.ADDITIONChloroform and an aqueous potassium carbonate solution were added
5. 5
   その他the chloroform layer was separated
6. 6
   乾燥The layer was dried over magnesium sulfate
7. 7
   その他the solvent was evaporated under reduced pressure

実験手順

3-(3-(4-(4-Chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydroindole (0.5 g) obtained in Example 161 and potassium carbonate (0.6 g) were dissolved in dimethylformamide (10 ml) and methyl iodide (0.3 g) was added under ice-cooling with stirring. The reaction mixture was stirred at room temperature for 2 hours and the solvent was evaporated under reduced pressure. Chloroform and an aqueous potassium carbonate solution were added and the chloroform layer was separated. The layer was dried over magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography to give 3-(3-(4-(4-chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methylindole.

出典