反応 #7221

反応方程式

N-benzimidazolyl-1,2-propanediol

sodium periodate

→

2-(benzimidazol-1-yl)-ethanal

収率 41.2%

溶媒

water

反応条件

後処理

1. 1
   抽出The solution was then extracted with dichloromethane
2. 2
   乾燥dried (MgSO4)
3. 3
   ろ過filtered
4. 4
   濃縮concentrated

実験手順

The intermediate, N-benzimidazolyl-1,2-propanediol (0.66 g, 3.4 mmol) from above was dissolved in water (25 mL) and treated with sodium periodate (0.88 g, 4.1 mmol) with stirring for 1.5 hours. The solution was then extracted with dichloromethane, dried (MgSO4), filtered and concentrated to yield 2-(benzimidazol-1-yl)-ethanal (0.22 g, 1.4 mmol) which was used immediately without further purification in the next reaction.

出典