反応 #72200

反応方程式

cis(±)-3-(tert-butoxycarbonyl)amino-2-ethylazetidine

cis(±)-3-(tert-Butoxycarbonyl)amino-2-ethylazetidine

ethyl 2-bromo-4-methylthiazole-5-carboxylate

diisopropylethylamine

→

title compound

収率 84.0%

Ethyl cis(±)-2-{3-[(tert-butoxycarbonyl)amino]-2-ethylazetidin-1-yl}-4-methyl-1,3-thiazole-5-carboxylate

収率 84.0%

反応条件

実験手順

The same operation as in Example (232c) was performed using cis(±)-3-(tert-butoxycarbonyl)amino-2-ethylazetidine obtained in Example (235f) (66 mg, 0.33 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (82 mg, 0.33 mmol) and diisopropylethylamine (0.12 mL, 0.66 mmol), to obtain 102 mg of the title compound as a white solid (84%).

出典