反応 #72194

反応方程式

trans(±)-3-(tert-butoxycarbonyl)amino-2-ethylazetidine

trans(±)-3-(tert-Butoxycarbonyl)amino-2-ethylazetidine

ethyl 2-bromo-4-methylthiazole-5-carboxylate

diisopropylethylamine

→

title compound

収率 76.8%

Ethyl trans(±)-2-{3-[(tert-butoxycarbonyl)amino]-2-ethylazetidin-1-yl}-4-methyl-1,3-thiazole-5-carboxylate

収率 76.8%

反応条件

実験手順

The same operation as in Example (232c) was performed using trans(±)-3-(tert-butoxycarbonyl)amino-2-ethylazetidine obtained in Example (234e) (110 mg, 0.55 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (137 mg, 0.55 mmol) and diisopropylethylamine (0.19 mL, 1.10 mmol), to obtain 156 mg of the title compound as a pale yellow oily substance (77%).

出典