反応 #721860

反応方程式

ammonia

7-acetoxy4-(5-benzyloxy-2-fluoro-4-methylanilino)-6-methoxyquinazoline

→

4-(5-benzyloxy-2-fluoro-4-methylanilino)-7-hydroxy-6-methoxyquinazoline

収率 89.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他most of the organic volatiles were then removed by evaporation
2. 2
   workup.ADDITIONFurther water was added
3. 3
   ろ過the precipitate was collected by filtration
4. 4
   洗浄washed with water
5. 5
   その他dried

実験手順

Concentrated aqueous ammonia (25 ml) was added to a solution of 7-acetoxy4-(5-benzyloxy-2-fluoro-4-methylanilino)-6-methoxyquinazoline (1.5 g, 3.4 mmol) in methanol (100 ml). The mixture was stirred at ambient temperature for 30 minutes, and most of the organic volatiles were then removed by evaporation. Further water was added and the precipitate was collected by filtration, washed with water and dried to give 4-(5-benzyloxy-2-fluoro-4-methylanilino)-7-hydroxy-6-methoxyquinazoline (1.2 g, 89%) which was used without further characterisation.

出典