反応 #721856

反応方程式

4-fluoro-2-methyl-5-nitrophenol

benzyl bromide

potassium carbonate

→

5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene

収率 90.7%

溶媒

DMF

water

反応条件

後処理

1. 1
   その他(prepared
2. 2
   温度to cool
3. 3
   ろ過The precipitated product was collected by filtration
4. 4
   洗浄washed with water
5. 5
   その他dried

実験手順

A mixture of 4-fluoro-2-methyl-5-nitrophenol (4.69 g, 27 mmol), (prepared as described for the starting material in Example 8), benzyl bromide (3.59 ml, 30 mmol) and potassium carbonate (7.58 g, 55 mmol) in DMF (100 ml) was heated at 80° C. for 4 hours. The reaction mixture was allowed to cool and diluted with water and stirred for 15 minutes. The precipitated product was collected by filtration, washed with water and dried to give 5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (6.4 g, 89%).

出典