反応 #721855

反応方程式

7-(2-acetoxyethoxy)-4-(5-benzyloxy-2-fluoro-4-methylanilino)-6-methoxyquinazoline

hydrogen

→

7-(2-acetoxyethoxy)-4-(2-fluoro-5-hydroxy4-methylanilino)-6-methoxyquinazoline

収率 15.0%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration through diatomaceous earth and most of the solvent
2. 2
   その他removed by evaporation and hexane
3. 3
   workup.ADDITIONadded to the residue
4. 4
   その他The resulting precipitated product
5. 5
   ろ過was collected by filtration
6. 6
   その他dried

実験手順

A mixture of 7-(2-acetoxyethoxy)-4-(5-benzyloxy-2-fluoro-4-methylanilino)-6-methoxyquinazoline (133 mg, 0.27 mmol) and 10% palladium-on-charcoal catalyst (50 mg) in ethyl acetate (8 ml) was stirred under 1 atmosphere of hydrogen at ambient temperature for 18 hours. The catalyst was removed by filtration through diatomaceous earth and most of the solvent removed by evaporation and hexane added to the residue. The resulting precipitated product was collected by filtration and dried to give 7-(2-acetoxyethoxy)-4-(2-fluoro-5-hydroxy4-methylanilino)-6-methoxyquinazoline (16 mg, 15%).

出典