反応 #72110

反応方程式

ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate

→

title compound

収率 57.8%

Ethyl 3-(4-aminocyclohex-1-enyl)benzoate

収率 57.8%

溶媒

hydrochloric acid 1,4-dioxane

反応条件

後処理

1. 1
   その他the solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol
3. 3
   workup.ADDITIONAmberlite IRA-400(Cl) ion exchange resin (20 g) was added
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for one hour
5. 5
   ろ過Amberlite was filtered off
6. 6
   濃縮the solution was concentrated under reduced pressure

実験手順

A 4 N hydrochloric acid/1,4-dioxane solution (20 mL) was added to ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate obtained in Example (195b) (510 mg, 1.48 mmol). The mixture was stirred at room temperature for one hour, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in methanol. Amberlite IRA-400(Cl) ion exchange resin (20 g) was added, and the mixture was stirred at room temperature for one hour. Amberlite was filtered off, and then the solution was concentrated under reduced pressure to obtain 210 mg of the title compound as a colorless oily substance.

出典