反応 #7202

反応方程式

1-bromo-3,3-dimethyl-butan-2-one

formamide

CH2Cl2 MeOH NH4OH

→

title compound

収率 21.0%

5-tert-Butyl-1H-imidazole

収率 21.0%

反応条件

実験手順

Reaction of 1-bromo-3,3-dimethyl-butan-2-one (3.0 g, 16.80 mmol), and formamide (4.7 mL, 117.20 mmol), followed by chromatography (CH2Cl2/MeOH/NH4OH 94:3:3) gave the title compound (450 mg, 21%) as a yellow foam. 1H NMR (300 MHz, CDCl3) δ 1.29 (s, 9H), 6.77 (s, 1H), 7.57, (s, 1H). ES-MS m/z 125 (M+H).

出典