反応 #71997

反応方程式

Methyl chloroglyoxylate

triethylamine

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride

→

title compound

収率 90.7%

Methyl cis(±)-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)(oxo)acetate

収率 90.7%

溶媒

ethyl acetate

dichloromethane

反応条件

後処理

1. 1
   温度cooling
2. 2
   洗浄washed with water and brine
3. 3
   乾燥dried over anhydrous sodium sulfate
4. 4
   濃縮concentration under reduced pressure
5. 5
   その他the residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=7/3→1/0)

実験手順

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (200 mg, 0.593 mmol) was suspended in dichloromethane (5 mL). Methyl chloroglyoxylate (0.070 mL, 0.76 mmol), triethylamine (0.250 mL, 1.80 mmol) and DMAP (catalytic amount) were added under ice-cooling, and the mixture was stirred at room temperature for one hour. The reaction solution was diluted with ethyl acetate, washed with water and brine, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=7/3→1/0) to obtain 208.1 mg of the title compound as a colorless oily substance (91%).

出典