反応 #71934

反応方程式

tert-butyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate

sodium hydride

allyl iodide

→

title compound

収率 93.6%

tert-Butyl 3-allyloxy-4,4-dimethoxypiperidine-1-carboxylate

収率 93.6%

溶媒

DMF

反応条件

後処理

1. 1
   その他The residue was purified by column chromatography (elution solvent: hexane/ethyl acetate=10/1, 4/1, 2/1)

実験手順

The same operation as in Example (90a) was performed using tert-butyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate (5.2 g, 20 mmol), sodium hydride (55% content, 1.31 g, 30 mmol), allyl iodide (5.03 g, 30 mmol) and DMF (50 mL). The residue was purified by column chromatography (elution solvent: hexane/ethyl acetate=10/1, 4/1, 2/1) to obtain 5.64 g of the title compound as a colorless oily substance (93%).

出典