反応 #7192

反応方程式

acetophenone

acetic acid

bromine

→

title compound

収率 41.0%

2-Bromo-1-phenyl-ethanone

収率 41.0%

反応条件

後処理

1. 1
   その他followed by recrystallisation from cold EtOAc/Hexane

実験手順

Reaction of acetophenone (5.0 g, 42.00 mmol), acetic acid (2.4 mL, 42.00 mmol), and bromine (2.5 mL, 48.00 mmol) followed by recrystallisation from cold EtOAc/Hexane gave the title compound (3.4 g, 41%) as a white crystal. 1H NMR (300 MHz, CDCl3) δ 4.47 (s, 2H), 7.51 (d, 2H, J=7.5 Hz), 7.63 (t, 1H, J=7.5 Hz), 8.00 (d, 2H, J=7.2 Hz).

出典